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Tissues are the unsung hero of every office, home and classroom. When looking for quality cold and flu supplies, facial tissue minimizes discomfort and sniffling.

Choose the Right Tissue Thickness and Size
Brands produce tissue in a variety of dimensions and thicknesses, accommodating both occasional snifflers and heavy-duty nose blowers. The majority of tissue products have nearly square dimensions of about 8 by 8 inches, but some are smaller. Those who go through many tissues may get more value out of smaller options and can choose designs that are about half as wide. Smaller tissues save space and minimize paper waste. Tissue thickness is generally measured in plies. The single-ply tissue is made with one layer of paper. Single-ply options are considerably thinner than other designs, and they tend to maximize value for those who use substantial amounts of tissue. Two-ply and 3-ply tissues have additional layers, so they offer enhanced durability and strength.

Extra-Soft Tissues Cushion Sensitive Noses Frequent tissue use can irritate the skin, particularly during a severe cold or persistent allergies. Ultra-soft tissue options are ideal for these situations. They are gentle on the skin, minimizing the risk of redness and dryness. Extra-soft tissues often have extra plies for a thicker texture. Small air pockets inside each tissue provide further protection for delicate skin. Lotion-treated tissue products serve two purposes: They prevent skin friction and provide moisture in dry environments.

Battle Germs with Enhanced Tissue Products
Cold and flu season causes even the healthiest people to keep a box of facial tissue on hand at all times. When illness is the trigger for tissue use, consider specialized products that are designed to ease symptoms and help users heal more quickly. Antiviral tissue products often contain a middle layer that is activated by moisture. This layer kills up to 99.9 percent of cold and flu viruses. This type of tissue can prevent the spread of illness, especially in an office or classroom. Another popular option is a box of cooling tissues. These wipes contain lotion and cooling moisturizers that are released on contact, relieving nose redness and soreness.

Various Package Sizes Fit Home and Business Needs
Having facial tissue readily available is an important part of hygiene. That's why brands offer these products in a variety of package sizes. Individual tissue packs are small enough to fit in pockets, purses and briefcases. Boxes for the home and office come in rectangular and square designs to suit a variety of surfaces. Refill packs are ideal for tissue boxes that are part of a room's decor, and bulk ordering options make it easy to keep face tissues available in any number of rooms.

Eco-Friendly Tissues Help Users go Green
The disposable nature of facial tissues is what makes them hygienic, and with environmentally friendly options, users can shrink their carbon footprint. Several brands create Forest Stewardship Council certified tissues. Sustainable brands often use recycled fiber and avoid chlorine bleach. Whether you want extra-soft or antiviral, you'll find the ideal tissue variety for every home, business and school user at Staples.
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Kleenex Boutique Standard Facial Tissues, 2-Ply, 95 Sheets/Box, 6/Pack (21271)
Item: 826830 / Model : 21271
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  • Standard facial tissues are soft and gentle on the skin but tough on messes
  • 2-ply thickness offers outstanding quality and softness
  • Perfect tissue for when sore or runny noses need some extra non-lotion softness
12.79 $12.79
6/Pack
Get it by Mon, Feb 25
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Kleenex Standard Facial Tissues, 2-Ply, 100 Sheets/Box, 36 Boxes/Pack (21400)
Item: 808298 / Model : 21400CT
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  • Standard facial tissues are soft and gentle on the skin but tough on messes
  • 2-ply thickness offers outstanding quality and softness
  • Contains 36 boxes per pack for long-term use
45.99 $45.99 55.99 $55.99
36/Carton
Get it by Mon, Feb 25
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Price: $55.99
Instant Savings: -$10.00
$45.99*
36/Carton
*Price after savings
Puffs Plus Lotion Facial Tissues, 2-Ply, 56 Sheets/Box, 4 Boxes/Pack (34899)
Item: 1917288 / Model : 34899
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  • Lotion tissues help soothe irritated noses by locking in moisture better than regular tissues
  • 2-ply thickness offers outstanding quality and softness
  • Contains four boxes per pack for long-term use
6.29 $6.29
4/Pack
Get it by Mon, Feb 25
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Staples Choice
Staples Facial Tissues Single Cube Box, 2-Ply, 95 Sheets/Box, 36 Boxes/Case
Staples Facial Tissues Single Cube Box, 2-Ply, 95 Sheets/Box, 36 Boxes/Case
Item: 24322422 / Model : 53222CT
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  • 2-Ply Facial Tissue
  • Strong and Absorbent
  • 36 cube boxes/case
46.59 $46.59
36/Carton
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Kleenex Boutique Standard Facial Tissue, 2-Ply, 95 Sheets/Box, 36 Boxes/Pack (21270)
Item: 915714 / Model : 21270
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  • Standard facial tissues are soft and gentle on the skin but tough on messes
  • 2-ply thickness offers outstanding quality and softness
  • Contains 36 boxes per pack for long-term use
78.69 $78.69
36/Carton
Get it by Mon, Feb 25
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Staples Facial Tissues Flat Box, 2-Ply, 160 Sheets/Box, 4 Boxes/Pack
Item: 24322419 / Model : 53224
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  • 2-Ply Facial Tissue
  • Strong and Absorbent
  • 4 flat boxes/pack
4.69 $4.69
4/Pack
Get it by Mon, Feb 25
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Staples Facial Tissues Flat Box, 2-Ply, 160 Sheets/Box, 36 Boxes/Case
Item: 24322423 / Model : 53223CT
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  • 2-Ply Facial Tissue
  • Strong and Absorbent
  • 36 flat boxes/case
45.59 $45.59
36/Carton
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Puffs Ultra Soft & Strong Standard Facial Tissues, 2-Ply, 56 Sheets/Box, 4 Boxes/Pack (35295)
Item: 2675854 / Model : 35295
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  • Lotion tissues help soothe irritated noses by locking in moisture better than regular tissues
  • 2-ply thickness offers outstanding quality and softness
  • Contains four boxes per pack for long-term use
6.29 $6.29
4/Pack
Get it by Mon, Feb 25
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Puffs Ultra Soft and Strong Standard Facial Tissue, 2-Ply, 56 Sheets/Box, 24 Boxes/Pack (35295CT)
Item: 2676177 / Model : 35295CT
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  • Standard facial tissues are soft and gentle on the skin but tough on messes
  • 2-ply thickness offers outstanding quality and softness
  • Contains 24 boxes per pack for long-term use
32.59 $32.59
24/Carton
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Kleenex multicare Facial Tissues; 80 Tissues per Box, 4 pack
Item: 2637745 / Model : 46356
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  • Rely on durable; 2-ply thickness paper tissue sheets
  • Absorbent; disposable facial tissues lock in moisture
  • Tissue boxes with 80 tissues per box
7.09 $7.09
4/Pack
Get it by Mon, Feb 25
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Kleenex Boutique Standard Facial Tissue, 2-Ply, 95 Sheets/Box (21270)
Item: 477898 / Model : 21270
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  • Standard facial tissues are soft and gentle on the skin but tough on messes
  • 2-ply thickness offers outstanding quality and softness
  • Contains one box per pack
2.49 $2.49
95/Box
Get it by Mon, Feb 25
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Staples Facial Tissues Flat Box, 2-Ply, 160 Sheets/Box, Single Box
Item: 24322421 / Model : 53223
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  • 2-Ply Facial Tissue
  • Strong and Absorbent
  • Sold in 1/PK
1.79 $1.79
Each
Get it by Mon, Feb 25
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Staples Facial Tissues Cube Box, 2-Ply, 95 Sheets/Box, Single Box
Item: 24322420 / Model : 53222
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  • 2-Ply Facial Tissue
  • Strong and Absorbent
  • Sold in 1/PK
1.69 $1.69
Each
Get it by Mon, Feb 25
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Puffs® Cube Ultra Soft 2-Ply Facial Tissues, 56/Box
Item: 1560503 / Model : 35038
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  • Air-Fluffed™ pillows for a more cushiony feel
  • Great for every room in the house
  • Designed for everything your face has to face
2.19 $2.19
Each
Get it by Mon, Feb 25
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Kleenex Go Pack Facial Tissues, 3-Ply, 3 Pouches/Pack, 10 Sheets/Pouch
Item: 161851 / Model : 11976
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  • 3 pouches per pack
  • 10 tissues per pouch
  • 3-ply white
3.79 $3.79
3/Pack
Get it by Mon, Feb 25
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Puffs Basic Family Pack 2-Ply Facial Tissues, Unscented, 6 x 180 Count (84327)
Item: 24380334 / Model : 87622
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  • Pack includes 6 Family Boxes (180 Tissues per Box) of Puffs, everyday non-lotion facial tissues
  • Each tissue has Puffs cushiony softness
  • Soft and 50% stronger when wet vs. the leading bargain brand
13.99 $13.99
Each
Get it by Mon, Feb 25
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Puffs Ultra Soft Facial Tissue Cube, 2-Ply, 56 Sheets/Cube, 24 Pack/Carton (35038CT)
Item: 24309368 / Model : 35038CT
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  • Soft, strong and fragrance free tissues that contain no lotion
  • 56 Puff tissues in a cube
  • 24 cartons of Puff cube
47.99 $47.99 49.99 $49.99
24/Carton
Get it by Mon, Feb 25
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Price: $49.99
Instant Savings: -$2.00
$47.99*
24/Carton
*Price after savings
Angel Soft Ultra Professional Series Standard Facial Tissues, 2-Ply, 125 Sheets/Box, 10 Boxes/Pack (4836014)
Item: 1279018 / Model : 4836014
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  • Standard facial tissues are soft and gentle on the skin but tough on messes
  • 2-ply thickness offers outstanding quality and softness
  • Contains 10 boxes per pack for long-term use
29.59 $29.59
10/Carton
Get it by Mon, Feb 25
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Kleenex Standard Facial Tissue, 2-Ply, 100 Sheets/Box (21400)
Item: 378137 / Model : 21400
Add to Favorites
  • Standard facial tissues are soft and gentle on the skin but tough on messes
  • 2-ply thickness offers outstanding quality and softness
  • Contains one box per pack
2.09 $2.09
100/Box
Get it by Mon, Feb 25
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Kleenex 2-Ply Everyday Facial Tissues, 160 Tissues per Flat Box (37390)
Item: 24296567 / Model : 37390
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  • Kleenex Everyday Tissues offer gentle care for face and hands
  • Rely on durable, 2-ply thickness paper tissue sheets
  • Absorbent, disposable facial tissues lock in moisture
4.99 $4.99
Each
Kleenex 2-Ply Everyday Facial Tissues, 160 Tissues per Flat Box, 3 Pack + 24ct. Wet Wipes Bonus (48893)
Item: 24296570 / Model : 48893
Add to Favorites
  • Kleenex Everyday Tissues offer gentle care for face and hands
  • Rely on durable; 2-ply thickness paper tissue sheets
  • Absorbent; disposable facial tissues lock in moisture
4.99 $4.99
Each